Increased left ventricular extracellular volume and enhanced twist function in type 1 diabetic individuals

Increased Left Ventricular Torsion in Uncomplicated Type 1 Diabetic Patients

OBJECTIVE We used speckle tracking echocardiography to study the early changes in left ventricular (LV) torsion in young patients with uncomplicated type 1 diabetes and stress magnetic resonance imaging (MRI) to assess its interrelationships with coronary microangiopathy. RESEARCH DESIGN AND METHODS We recruited 33 asymptomatic subjects with type 1 diabetes and 32 age-matched healthy control ...

Subclinical Left Ventricular Dysfunction in Asymptomatic Type 1 Diabetic Children

J Cardiol Curr Res 2016, 6(6): 00229 measurement of left ventricular ejection fraction (LVEF) using standard two-dimensional (2D) echocardiography [2,3]. However, the LV contractility is a complex mechanism resulting from a three-dimensional structure. Myocardial fibers are orientated in different directions and responsible for three principal types of deformation: longitudinal; radial and circ...

Left Ventricular Twist in Cardiomyopathy

Increased left ventricular torsion in uncomplicated type 1 diabetes: the role of coronary microvascular function

This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisherauthenticated version will be available in a future issue of Diabetes Care in pr...

Increased Expression of TRAIL and Its Receptors on Peripheral T-Cells in Type 1 Diabetic Patients

Background: Type-I diabetes is an autoimmune inflammatory disease in which pancreatic ß-cells are selectively destroyed by infiltrating cells. TNF-related apoptosis-inducing ligand (TRAIL) is a type-II membrane protein of the TNF superfamily which is expressed in different tissues, including pancreas and lymphocytes. In humans, TRAIL interacts with four membrane receptors. TRAIL-R1 and TRAIL-R2...